T cell replicative senescence in human aging.

  title={T cell replicative senescence in human aging.},
  author={Jennifer P. Chou and Rita B. Effros},
  journal={Current pharmaceutical design},
  volume={19 9},
The decline of the immune system appears to be an intractable consequence of aging, leading to increased susceptibility to infections, reduced effectiveness of vaccination and higher incidences of many diseases including osteoporosis and cancer in the elderly. These outcomes can be attributed, at least in part, to a phenomenon known as T cell replicative senescence, a terminal state characterized by dysregulated immune function, loss of the CD28 costimulatory molecule, shortened telomeres and… CONTINUE READING
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