T-cell regulator RNF125/TRAC-1 belongs to a novel family of ubiquitin ligases with zinc fingers and a ubiquitin-binding domain.

@article{Giannini2008TcellRR,
  title={T-cell regulator RNF125/TRAC-1 belongs to a novel family of ubiquitin ligases with zinc fingers and a ubiquitin-binding domain.},
  author={Ana Lucia Giannini and Yifang Gao and Marie-Jos{\'e} Bijlmakers},
  journal={The Biochemical journal},
  year={2008},
  volume={410 1},
  pages={101-11}
}
The recently identified RNF125 [RING (really interesting new gene) finger protein 125], or TRAC-1 (T-cell RING protein in activation 1), is unique among ubiquitin ligases in being a positive regulator of T-cell activation. In addition, TRAC-1 has been shown to down-modulate HIV replication and to inhibit pathogen-induced cytokine production. However, apart… CONTINUE READING