T-cell reconstitution by molecular, phenotypic, and functional analysis in the thymus, bone marrow, spleen, and blood following split-dose polychemotherapy and therapeutic activity for metastatic breast cancer in mice.

@article{Talmadge1993TcellRB,
  title={T-cell reconstitution by molecular, phenotypic, and functional analysis in the thymus, bone marrow, spleen, and blood following split-dose polychemotherapy and therapeutic activity for metastatic breast cancer in mice.},
  author={James E Talmadge and John David Jackson and Linda J. Kelsey and Claudia D. Borgeson and Connie R. Faltynek and George A. Perry},
  journal={Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy},
  year={1993},
  volume={14 4},
  pages={
          258-68
        }
}
We examined the effect of a maximum tolerated, split-dose chemotherapy protocol of cyclophosphamide, cisplatin, and 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) on neutrophil and lymphocyte subpopulations in the peripheral blood leukocytes (PBLs), thymus, bone marrow, and spleen. It was found that this protocol of polychemotherapy, modeled after the induction protocol used with autologous bone marrow transplantation (AuBMT) for breast cancer, suppressed both B- and T-cell populations and T-cell… CONTINUE READING