T cell reconstitution after bone marrow transplantation into adult patients does not resemble T cell development in early life.

@article{Storek1995TCR,
  title={T cell reconstitution after bone marrow transplantation into adult patients does not resemble T cell development in early life.},
  author={Jan Storek and Robert P. Witherspoon and Rainer F Storb},
  journal={Bone marrow transplantation},
  year={1995},
  volume={16 3},
  pages={
          413-25
        }
}
Immune reconstitution after marrow transplantation has some characteristics of immune development in early life. Here we provide phenotypic data suggesting this may not be true for T cells (particularly CD4+ T cells) in the case of marrow transplantation into adults. T cells from 35 adult patients at 1 year after transplant, 14 normal neonates and 22 normal adults were studied by 3-color flow cytometry. Marked disparity between the phenotype of neonatal vs post-transplant T cells was found. Of… CONTINUE READING

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