T-cell recognition of tumor-associated carbohydrates: the nature of the glycan moiety plays a decisive role in determining glycopeptide immunogenicity.

@article{GalliStampino1997TcellRO,
  title={T-cell recognition of tumor-associated carbohydrates: the nature of the glycan moiety plays a decisive role in determining glycopeptide immunogenicity.},
  author={Luisa Galli-Stampino and Ernst Meinjohanns and Klaus Frische and Morten Meldal and Teis Jensen and Ole Werdelin and S\oren Mouritsen},
  journal={Cancer research},
  year={1997},
  volume={57 15},
  pages={
          3214-22
        }
}
Aberrant glycosylation is one of the most constant traits of the malignant cell phenotype. To study T-cell responses to tumor-associated glycans, the mouse hemoglobin-derived decapeptide Hb(67-76), which binds well to the MHC class II molecule E(k) and is nonimmunogenic in CBA/J mice, was either O- or N-glycosylated at its primary T-cell receptor contact residue, position 72, with different glycans attached to either threonine, serine, or asparagine. The carbohydrate moieties included tumor… CONTINUE READING
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Synthesis and charac terizationof highlyglycosylatedglycopeptideswithTn antigenicstructurescorre spending to human glycophorin AN

G. Klich, H. Paulsen, B. Meyer, M. Meldal, K. Bock
Carbohydr. Rca., • 1997

Efficient synthesis ofcore 1, core 2, core 3, and core 4 building blocks for solid-phase synthesis of mucin glycopeptides

E. Meinjohanns, M. Melds, H. Paulsen, A. Schleyer, K. Bock
J. Chem. Soc. Perkin Trans., • 1996

Sensitivity of glycopeptide conformation to carbohydrate chain length

R. Liang, A. H. Andreotti, D. Kahne
J. Am. Chem. Soc., • 1995

Crystalstructureofthe humanclass IIMHCproteinHLA-DR1 complexed with an influenza virus peptide

L. J. Stern, J. H. Brown, +4 authors D. C. andWiley
Nature (Lond.), • 1994

Three-dimensional structure of the human class H histocom patibility antigen HLA-DRI

J. H. Brown, T. S. Jardetzky, +4 authors D. C. Wiley
Nature (Lond.), • 1993