T cell recognition of myelin proteolipid protein and myelin proteolipid protein peptides in the peripheral blood of multiple sclerosis and control subjects.

@article{Trotter1998TCR,
  title={T cell recognition of myelin proteolipid protein and myelin proteolipid protein peptides in the peripheral blood of multiple sclerosis and control subjects.},
  author={John L. Trotter and Clara M. Pelfrey and A L Trotter and Jacqueline A Selvidge and K C Gushleff and Thallachallour Mohanakumar and Henry F. McFarland},
  journal={Journal of neuroimmunology},
  year={1998},
  volume={84 2},
  pages={172-8}
}
Myelin proteolipid protein (PLP) is a prime candidate autoantigen for multiple sclerosis. In order to define potential immunodominant epitopes, T cell lines (TCL) from the peripheral blood of HLA-DR 15(2) MS patients were established which responded to the intact molecule of PLP. These TCL were then tested in individual proliferation assays with a variety of PLP peptides spanning most of the PLP molecule. Multiple peptides were recognized by TCL from the MS population, with more than one… CONTINUE READING
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