T cell recognition of human tumors: implications for molecular immunotherapy of cancer.

@article{Ioannides1993TCR,
  title={T cell recognition of human tumors: implications for molecular immunotherapy of cancer.},
  author={Constantin G. Ioannides and Theresa L Whiteside},
  journal={Clinical immunology and immunopathology},
  year={1993},
  volume={66 2},
  pages={91-106}
}
Based on experimental and clinical data, it appears that human T cells are capable of mediating tumor cell destruction and, thus, are potentially important for immunotherapy of cancer. To date, neither the mechanisms responsible for T cell-mediated tumor cell destruction in vivo nor in vitro correlates of clinical responses in cancer patients treated with immunotherapy have been defined. Nevertheless, substantial evidence for the presence in cancer patients of specific autotumor (AuTu… CONTINUE READING
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