T cell recognition and tolerance of antibody diversity.

  title={T cell recognition and tolerance of antibody diversity.},
  author={M C Eyerman and Xiaoli Zhang and Lawrence J Wysocki},
  journal={Journal of immunology},
  volume={157 3},
The capacity of B cells to self-present their Ab variable regions in the context of class II MHC structures suggests a potential regulatory problem. If T cells were able to recognize self-presented Ab, then T cell help might be delivered to B cells independently of a foreign carrier epitope, resulting in a chronic state of unregulated Ab synthesis. For this reason, we have proposed that T cells normally attain a state of tolerance to Ab V region diversity. Here, we tested this idea by… CONTINUE READING

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