T-cell receptors and rheumatic disease: approaches to repertoire analysis.


T-lymphocytes are thought to play a major role in the pathogenesis of a number of autoimmune rheumatic diseases. Techniques have recently been developed to study the T-cell receptor (TCR) usage of individual T-cells, and are likely to give major insight into the pathogenesis of rheumatic diseases. We describe the development of the TCR repertoire and the… (More)


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