T-cell receptor variable genes and genetic susceptibility to celiac disease: an association and linkage study.

@article{Roschmann1993TcellRV,
  title={T-cell receptor variable genes and genetic susceptibility to celiac disease: an association and linkage study.},
  author={E. Roschmann and Thomas F. Wienker and Wolfgang Gerok and Brigitte Agnes Volk},
  journal={Gastroenterology},
  year={1993},
  volume={105 6},
  pages={1790-6}
}
BACKGROUND Genetic susceptibility of celiac disease is primarily associated with a particular combination of and HLA-DQA1/DQB1 gene; however, this does not fully account for the genetic predisposition. Therefore, the aim of this study was to examine whether T-cell receptor (TCR) genes may be susceptibility genes in celiac disease. METHODS HLA class II typing was performed by polymerase chain reaction amplification in combination with sequence-specific oligonucleotide hybridization. TCR alpha… CONTINUE READING