T cell receptor signalling networks: branched, diversified and bounded

@article{Brownlie2013TCR,
  title={T cell receptor signalling networks: branched, diversified and bounded},
  author={Rebecca J Brownlie and Rose Zamoyska},
  journal={Nature Reviews Immunology},
  year={2013},
  volume={13},
  pages={257-269}
}
Engagement of antigen-specific T cell receptors (TCRs) is a prerequisite for T cell activation. Acquisition of appropriate effector T cell function requires the participation of multiple signals from the T cell microenvironment. Trying to understand how these signals integrate to achieve specific functional outcomes while maintaining tolerance to self is a major challenge in lymphocyte biology. Several recent publications have provided important insights into how dysregulation of T cell… CONTINUE READING
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