T-cell receptor retrogenic mice: a rapid, flexible alternative to T-cell receptor transgenic mice.


The T-cell receptor (TCR) is unique in its complexity. It determines not only positive (life) and negative (death) selection in the thymus, but also mediates proliferation, anergy, differentiation, cytotoxicity and cytokine production in the periphery. Through its association with six CD3 signalling chains (εγ, δε and ζζ), the TCR is capable of recognizing… (More)
DOI: 10.1111/j.1365-2567.2012.03574.x


5 Figures and Tables