T cell receptor mimic peptides and their potential application in T-cell-mediated disease.

@article{Enk2000TCR,
  title={T cell receptor mimic peptides and their potential application in T-cell-mediated disease.},
  author={Alexander H Enk and Juergen Knop},
  journal={International archives of allergy and immunology},
  year={2000},
  volume={123 4},
  pages={275-81}
}
BACKGROUND A T cell receptor (TCR) peptide was designed that mimics the intramembranous amino acid sequence of the TCR chain. Prior studies had shown that this mimic peptide would inhibit TCR signaling. This study was designed to investigate the use of this mimic peptide for the treatment of T-cell-mediated skin diseases. METHODS Synthesized mimic peptides were first tested for their T-cell-inhibitory effect in proliferation assays. Afterwards, mimic peptides were applied to murine ear skin… CONTINUE READING