T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection.

@article{Clayton1997TcellRL,
  title={T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection.},
  author={Linda K. Clayton and Yoseph Ghendler and Emiko Mizoguchi and Raymond J. Patch and Timothy Ocain and Kim Orth and Atul K. Bhan and Vishva M. Dixit and Elli L. Reinherz},
  journal={The EMBO journal},
  year={1997},
  volume={16 9},
  pages={2282-93}
}
T-cell receptors (TCRs) are created by a stochastic gene rearrangement process during thymocyte development, generating thymocytes bearing useful, as well as unwanted, specificities. Within the latter group, autoreactive thymocytes arise which are subsequently eliminated via a thymocyte-specific apoptotic mechanism, termed negative selection. The molecular basis of this deletion is unknown. Here, we show that TCR triggering by peptide/MHC ligands activates a caspase in double-positive (DP) CD4… CONTINUE READING
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