T cell receptor excision circle assessment of thymopoiesis in aging mice.

@article{Sempowski2002TCR,
  title={T cell receptor excision circle assessment of thymopoiesis in aging mice.},
  author={Gregory D Sempowski and Maria E. Gooding and H. X. Liao and Phong T. Le and Barton F Haynes},
  journal={Molecular immunology},
  year={2002},
  volume={38 11},
  pages={841-8}
}
Signal joint T cell receptor delta (TCRD) excision circles (TRECs) are episomal DNA circles generated by the DNA recombination process that is used by T lymphocytes to produce antigen-specific alpha/beta T cell receptors. Measurement of TRECs in thymocytes and peripheral blood T cells has been used to study thymus output in chickens and humans. We have developed a real-time quantitative-PCR assay for the specific detection and quantification of mouse TCRD episomal DNA circles excised from the… CONTINUE READING

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