T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

@article{Dustin1989TcellRC,
  title={T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1},
  author={Michael L. Dustin and Timothy A Springer},
  journal={Nature},
  year={1989},
  volume={341},
  pages={619-624}
}
Effective interaction between T cells and their targets requires that recognition of specific antigen be coordinated with increased cell-cell adhesion. We show that antigen-receptor cross-linking increases the strength of the adhesion mechan-ism between lymphocyte function-associated molecule-1 (LFA-1) and intercellular adhesion molecules (ICAMs), with intracellular signals trans-mitted from the T-cell antigen receptor to the LFA-1 adhesion molecule. The increase in avidity is rapid and… CONTINUE READING
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