T cell receptor binding affinity governs the functional profile of cancer-specific CD8+ T cells

@inproceedings{Tan2015TCR,
  title={T cell receptor binding affinity governs the functional profile of cancer-specific CD8+ T cells},
  author={Mai Ping Tan and Andrew B. Gerry and Joanna E. Brewer and Luca Melchiori and John Stephen Bridgeman and Alan D. Bennett and Nicholas J. Pumphrey and Bent K. Jakobsen and David A. Price and Kristin Ladell and Andrew K. Sewell},
  booktitle={Clinical and experimental immunology},
  year={2015}
}
Antigen-specific T cell receptor (TCR) gene transfer via patient-derived T cells is an attractive approach to cancer therapy, with the potential to circumvent immune regulatory networks. However, high-affinity tumour-specific TCR clonotypes are typically deleted from the available repertoire during thymic selection because the vast majority of targeted epitopes are derived from autologous proteins. This process places intrinsic constraints on the efficacy of T cell-based cancer vaccines and… CONTINUE READING
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