T cell receptor beta chain gene rearrangement and selection during thymocyte development in adult mice.

@article{Dudley1994TCR,
  title={T cell receptor beta chain gene rearrangement and selection during thymocyte development in adult mice.},
  author={Erastus C. Dudley and Howard T. Petrie and L M Shah and Michael J Owen and Adrian C. Hayday},
  journal={Immunity},
  year={1994},
  volume={1 2},
  pages={83-93}
}
The identification is made in normal mice of the stages in T cell development at which the rearranged beta chain of the T cell receptor (TCR) is utilized to promote T cell maturation, independent of the TCR alpha chain. In addition, evidence is provided that utilization of beta chains in T cell progenitors does not preclude differentiation to TCR gamma delta + T cells. This is consistent with the view that an initial consequence of beta chain expression by early thymocytes is clonal expansion… CONTINUE READING