T cell receptor antagonist peptides are highly effective inhibitors of experimental allergic encephalomyelitis.

@article{Franco1994TCR,
  title={T cell receptor antagonist peptides are highly effective inhibitors of experimental allergic encephalomyelitis.},
  author={Alessandra Franco and Scott Southwood and Thomas Arrhenius and Vijay K Kuchroo and Howard Grey and Alessandro Sette and Glenn Y. Ishioka},
  journal={European journal of immunology},
  year={1994},
  volume={24 4},
  pages={940-6}
}
The feasibility of using T cell receptor (TcR) antagonist peptides to inhibit autoimmune disease has been examined. First, the fine antigenic structure of the I-As-restricted encephalitogenic determinant proteolipid protein (PLP) 139-151 has been analyzed. It was found that residues 145 and 148 were I-As anchor residues, and residue 144 appeared to be especially critical in T cell activation. Residues 142, 143, 146, and 147 were found to be crucial for activation of some, but not all, of the T… CONTINUE READING

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