T cell receptor β-chain repertoire analysis reveals intratumour heterogeneity of tumour-infiltrating lymphocytes in oesophageal squamous cell carcinoma.

@article{Chen2016TCR,
  title={T cell receptor β-chain repertoire analysis reveals intratumour heterogeneity of tumour-infiltrating lymphocytes in oesophageal squamous cell carcinoma.},
  author={Zengchao Chen and Chaoting Zhang and Yaqi Pan and Ruiping Xu and Changqing Xu and Ziping Chen and Zheming Lu and Y. H. Ke},
  journal={The Journal of pathology},
  year={2016},
  volume={239 4},
  pages={450-8}
}
Oesophageal squamous cell carcinoma (ESCC) has a generally poor prognosis, due to the lack of effective treatment methods. Immunotherapeutic approaches based on tumour-infiltrating lymphocytes (TILs) have demonstrated that durable responses are produced in some patients with solid tumours, which suggests the potential feasibility of clinical application of immunotherapy for ESCC. However, many of the basic characteristics of TILs in ESCC are poorly understood, including clonality, specificity… CONTINUE READING
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