T cell receptor (TCR) recognition of MHC class I variants: intermolecular second-site reversion provides evidence for peptide/MHC conformational variation

@article{Dyall1996TCR,
  title={T cell receptor (TCR) recognition of MHC class I variants: intermolecular second-site reversion provides evidence for peptide/MHC conformational variation},
  author={Ruben Dyall and Daved H. Fremont and Stephen C Jameson and Janko Nikoli{\'c}-Z̆ugi{\'c}},
  journal={The Journal of Experimental Medicine},
  year={1996},
  volume={184},
  pages={253 - 258}
}
We investigated mechanistic differences in antigen presentation between murine MHC class I variants H-2K(b) and H-2K(bm)8. H-2K(bm)8 differs from H-2K(b) by four residues at the floor of the peptide-binding site, affecting its B pocket which interacts with the second (P2) residue of the peptide. The rest of the molecule, including the T cell receptor (TCR)-contacting residues, is identical to H-2K(b). Due to this variation, CTLs that recognize the ovalbumin 257-264 and HSV gB 498-505 peptides… CONTINUE READING
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