T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy.

@article{Yin2012TcellR,
  title={T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy.},
  author={Lei Yin and Frances Crawford and Philippa Marrack and John W. Kappler and Shaodong Dai},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 45},
  pages={18517-22}
}
T cell-mediated allergy to Ni(++) is one of the most common forms of allergic contact dermatitis, but how the T-cell receptor (TCR) recognizes Ni(++) is unknown. We studied a TCR from an allergic patient that recognizes Ni(++) bound to the MHCII molecule DR52c containing an unknown self-peptide. We identified mimotope peptides that can replace both the self-peptide and Ni(++) in this ligand. They share a p7 lysine whose εNH(2) group is surface-exposed when bound to DR52c. Whereas the TCR uses… CONTINUE READING
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