T-cell reactivity to GAD65 peptide sequences shared with coxsackie virus protein in recent-onset IDDM, post-onset IDDM patients and control subjects

@article{Schloot1997TcellRT,
  title={T-cell reactivity to GAD65 peptide sequences shared with coxsackie virus protein in recent-onset IDDM, post-onset IDDM patients and control subjects},
  author={Nanette C Schloot and Bart O Roep and Dale R. Wegmann and Liang Yu and Tian Bao Wang and George S. Eisenbarth},
  journal={Diabetologia},
  year={1997},
  volume={40},
  pages={332-338}
}
GAD65 is one of the major autoantigens associated with insulin-dependent diabetes mellitus (IDDM). The two peptides p17 and p18 of GAD65 that share sequence similarity with coxsackie virus (amino acid sequence identity: PEVKEK) appeared to be the major determinants of GAD65 recognized preferably by T cells from new-onset IDDM patients and their first degree relatives. In contrast, in our study unrelated control subjects frequently recognized the two GAD peptides (55 %, 16/29), similar to first… CONTINUE READING
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Characterization of diabetogenic, GAD65-specific T cell clones established from NOD mice

  • N Schloot, P Gottlieb, D Wegmann
  • Diabetes
  • 1996
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