T-cell reactivity against streptococcal antigens in the periphery mirrors reactivity of heart-infiltrating T lymphocytes in rheumatic heart disease patients.

@article{Guilherme2001TcellRA,
  title={T-cell reactivity against streptococcal antigens in the periphery mirrors reactivity of heart-infiltrating T lymphocytes in rheumatic heart disease patients.},
  author={Luiza Guilherme and Sandra Emiko Oshiro and Kellen Cristhina Fa{\'e} and Edecio Cunha-Neto and G Renesto and Anna Carla Goldberg and Ana Cristina Sayuri Tanaka and Pablo M A Pomerantzeff and Maria Helena Bittencourt Kiss and Cristina Silva and F. J. Laso Guzm{\'a}n and Manuel Elkin Patarroyo and Scott Southwood and Alessandro Sette and Jorge Agle Kalil},
  journal={Infection and immunity},
  year={2001},
  volume={69 9},
  pages={5345-51}
}
T-cell molecular mimicry between streptococcal and heart proteins has been proposed as the triggering factor leading to autoimmunity in rheumatic heart disease (RHD). We searched for immunodominant T-cell M5 epitopes among RHD patients with defined clinical outcomes and compared the T-cell reactivities of peripheral blood and intralesional T cells from patients with severe RHD. The role of HLA class II molecules in the presentation of M5 peptides was also evaluated. We studied the T-cell… CONTINUE READING

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