T cell proliferative responses of type 1 diabetes patients and healthy individuals to human hsp60 and its peptides.

@article{AbulafiaLapid1999TCP,
  title={T cell proliferative responses of type 1 diabetes patients and healthy individuals to human hsp60 and its peptides.},
  author={Rivka Abulafia-Lapid and Dana Elias and Itamar Raz and Yael Keren-Zur and Henri Atlan and Irun R. Cohen},
  journal={Journal of autoimmunity},
  year={1999},
  volume={12 2},
  pages={
          121-9
        }
}
T cell responses to peptide epitopes of the 60 kDa heat shock protein (hsp60) have been shown to play a role in the pathogenesis of type 1 insulin-dependent diabetes mellitus (IDDM) in mice. To test whether hsp60 autoimmunity might be involved in human type 1 diabetes, we studied T cell proliferative responses (stimulation index; SI) to intact human hsp60, to hsp60 peptides and to a recall antigen (tetanus toxoid) in 25 newly diagnosed type 1 diabetes patients, in 22 type 2 (non-insulin… CONTINUE READING
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