T cell progenitors emerge earlier than B cell progenitors in the murine fetal liver.

@article{Kawamoto2000TCP,
  title={T cell progenitors emerge earlier than B cell progenitors in the murine fetal liver.},
  author={Hiroshi Kawamoto and Tomokatsu Ikawa and Koichiro Ohmura and Shinji Fujimoto and Yoshimoto Katsura},
  journal={Immunity},
  year={2000},
  volume={12 4},
  pages={441-50}
}
The developmental potential of individual cells in the Lin-c-kit+CD45+IL-7R+ (IL-7R+) population from murine fetal liver was investigated using a clonal assay capable of determining the potential of a progenitor to give rise to myeloid, T, and B cells. Unipotent progenitors generating T cells (p-T) or B cells (p-B) but not other types of progenitors were found in the IL-7R+ population. A large proportion of progenitors at day 12 of gestation are p-T, whereas the frequency of p-T dramatically… CONTINUE READING

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