T cell priming in situ by intratracheally instilled antigen-pulsed dendritic cells.

@article{Havenith1993TCP,
  title={T cell priming in situ by intratracheally instilled antigen-pulsed dendritic cells.},
  author={Carin E G Havenith and Annette Breedijk and Michiel G. H. Betjes and Wim Calame and Robert H. J. Beelen and Elisabeth C. M. Hoefsmit},
  journal={American journal of respiratory cell and molecular biology},
  year={1993},
  volume={8 3},
  pages={319-24}
}
In the present study, splenic dendritic cells (DC) and alveolar macrophages (AM) were pulsed with antigen in vitro and subsequently intratracheally instilled to test whether these cells have the capacity to sensitize T cells in the draining lymph nodes of the lung. The data demonstrate that antigen-pulsed DC, instilled in the bronchoalveolar lumen, induce antigen-specific T cell priming in vivo in the draining lymph nodes. T cell priming is only seen with viable but not with killed antigen… CONTINUE READING
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