T cell polarization identifies distinct clinical phenotypes in scleroderma lung disease.

@article{Boin2008TCP,
  title={T cell polarization identifies distinct clinical phenotypes in scleroderma lung disease.},
  author={Francesco Boin and U De Fanis and Susan J Bartlett and Fredrick Wigley and Antony Rosen and Vincenzo Casolaro},
  journal={Arthritis and rheumatism},
  year={2008},
  volume={58 4},
  pages={1165-74}
}
OBJECTIVE Lung involvement is the leading cause of morbidity and mortality in systemic sclerosis (SSc; scleroderma), and interstitial lung disease (ILD) is the most common pulmonary manifestation. An abnormal profibrotic Th2/Tc2-polarized T cell response is postulated to mediate tissue damage and fibrosis. The aim of this study was to investigate whether a polarized T cell phenotype in SSc is associated with lung disease or other clinical manifestations of SSc. METHODS Circulating T cells… CONTINUE READING
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