T cell polarity at the immunological synapse is required for CD154-dependent IL-12 secretion by dendritic cells.

@article{Tourret2010TCP,
  title={T cell polarity at the immunological synapse is required for CD154-dependent IL-12 secretion by dendritic cells.},
  author={Marie Tourret and Sarah Gu{\'e}gan and Karine Chemin and St{\'e}phanie Dogniaux and Francesc Mir{\'o} and Armelle Bohineust and Claire Hivroz},
  journal={Journal of immunology},
  year={2010},
  volume={185 11},
  pages={6809-18}
}
Ag-specific interaction between T lymphocytes and dendritic cells (DCs) leads to both T cell and DC activation. CD154 (CD40 ligand)/CD40 interactions have been shown to play a major, although not exclusive, role in this functional cross-talk. Interactions between T cells and DCs are structured by an immunological synapse (IS), characterized by polarization of the T cell microtubule cytoskeleton toward the interacting DCs. Yet the role T cell polarization may play in T cell-induced DC activation… CONTINUE READING