T-cell modulation combined with intratumoral CpG cures lymphoma in a mouse model without the need for chemotherapy.

@article{Houot2009TcellMC,
  title={T-cell modulation combined with intratumoral CpG cures lymphoma in a mouse model without the need for chemotherapy.},
  author={Roch Houot and Ronald Levy},
  journal={Blood},
  year={2009},
  volume={113 15},
  pages={3546-52}
}
We have previously shown that intratumoral injection of CpG oligodeoxynucleotide plus systemic chemotherapy can induce a T-cell immune response against lymphoma and serve as a therapeutic vaccine to cure tumors in a murine model. Here, we demonstrate that antibody-mediated modulation of T cells increases the efficacy of CpG vaccination, thereby eliminating the need for chemotherapy. T-cell modulation was accomplished by targeting both effector and regulatory T-cell populations using systemic… CONTINUE READING
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