T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?

@article{Appel2010TCD,
  title={T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?},
  author={Stanley H. Appel and David R. Beers and Jenny S. Henkel},
  journal={Trends in immunology},
  year={2010},
  volume={31 1},
  pages={7-17}
}
Neuroinflammation is a pathological hallmark in Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS), and is characterized by activated microglia and infiltrating T cells at sites of neuronal injury. In PD and ALS, neurons do not die alone; neuronal injury is non-cell-autonomous and depends on a well-orchestrated dialogue in which neuronally secreted misfolded proteins activate microglia and initiate a self-propagating cycle of neurotoxicity. Diverse populations and phenotypes of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 94 extracted citations

Similar Papers

Loading similar papers…