T-cell metagene predicts a favorable prognosis in estrogen receptor-negative and HER2-positive breast cancers

@article{Rody2008TcellMP,
  title={T-cell metagene predicts a favorable prognosis in estrogen receptor-negative and HER2-positive breast cancers},
  author={Achim Rody and Uwe Holtrich and Lajos Pusztai and Cornelia Liedtke and Regine Gaetje and Eugen Ruckhaeberle and Christine Solbach and Lars Christian Hanker and Andr{\'e} Ahr and D. Metzler and K. A. Engels and Thomas Karn and Manfred Kaufmann},
  journal={Breast Cancer Research : BCR},
  year={2008},
  volume={11},
  pages={R15 - R15}
}
Lymphocyte infiltration (LI) is often seen in breast cancer but its importance remains controversial. A positive correlation of human epidermal growth factor receptor 2 (HER2) amplification and LI has been described, which was associated with a more favorable outcome. However, specific lymphocytes might also promote tumor progression by shifting the cytokine milieu in the tumor. Affymetrix HG-U133A microarray data of 1,781 primary breast cancer samples from 12 datasets were included. The… CONTINUE READING
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Effects of infiltrating lymphocytes and estrogen receptor on gene expression and prognosis in breast cancer

  • A Calabrò, T Beissbarth, +8 authors H Sültmann
  • Breast Cancer Res Treat
  • 2008
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