T-cell-mediated rejection of the kidney in the era of donor-specific antibodies: diagnostic challenges and clinical significance.

@article{Randhawa2015TcellmediatedRO,
  title={T-cell-mediated rejection of the kidney in the era of donor-specific antibodies: diagnostic challenges and clinical significance.},
  author={Parmjeet Singh Randhawa},
  journal={Current opinion in organ transplantation},
  year={2015},
  volume={20 3},
  pages={
          325-32
        }
}
PURPOSE OF REVIEW Burgeoning literature on antibody-mediated rejection (ABMR) has led to a perception that T-cell-mediated rejection (TCMR) is no longer a significant problem. This premise needs to be carefully appraised. RECENT FINDINGS A review of the literature indicates that TCMR remains an independent-risk factor for graft loss. Importantly, it can occur as a sensitizing event that triggers ABMR, and adversely affects its outcome. Moreover, T cells are regularly present in lesions used… CONTINUE READING
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