T cell-mediated protection against lethal 2009 pandemic H1N1 influenza virus infection in a mouse model.

@article{Guo2011TCP,
  title={T cell-mediated protection against lethal 2009 pandemic H1N1 influenza virus infection in a mouse model.},
  author={Hailong Guo and F{\'e}lix M Santiago and Kris Lambert and Toru Takimoto and David J. Topham},
  journal={Journal of virology},
  year={2011},
  volume={85 1},
  pages={448-55}
}
Genetic mutation and reassortment of influenza virus gene segments, in particular those of hemagglutinin (HA) and neuraminidase (NA), that lead to antigenic drift and shift are the major strategies for influenza virus to escape preexisting immunity. The most recent example of such phenomena is the first pandemic of H1N1 influenza of the 21st century, which started in 2009. Cross-reactive antibodies raised against H1N1 viruses circulating before 1930 show protective activity against the 2009… CONTINUE READING

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