T cell-mediated maintenance of natural self-tolerance: its breakdown as a possible cause of various autoimmune diseases.


This paper shows that elimination of a small subpopulation of peripheral T cells can elicit activation/expansion of self-reactive T cells from the remaining T cells and produce a wide spectrum of organ-specific and systemic autoimmune diseases in normal mice; reconstitution of the eliminated T-cell population prevents autoimmune development. This regulatory… (More)


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