T cell lysis of murine renal cancer: multiple signaling pathways for cell death via Fas.

@article{Sayers2000TCL,
  title={T cell lysis of murine renal cancer: multiple signaling pathways for cell death via Fas.},
  author={Thomas Joseph Sayers and Alan David Brooks and Naohiko Seki and Mark J Smyth and H. Yagita and Bruce R Blazar and Anatoli M. Malyguine},
  journal={Journal of leukocyte biology},
  year={2000},
  volume={68 1},
  pages={81-6}
}
Activated T cells lyse the murine renal cancer Renca. We have examined the mechanism of tumor cell lysis with the use of T cells derived from C57BL/6, BALB/c, B6.gld, and B6.Pfp-/- mice. C57BL/6 and BALB/c T cells can lyse Renca cells through the use of both granule- and Fas ligand (FasL)-mediated pathways. However, B6.gld T cells predominantly use granule-mediated killing, whereas B6.Pfp-/- T cells use FasL. The lysis of Renca by Pfp-/- T cells is only partially inhibited by the caspase… CONTINUE READING

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