T cell long-term hyporesponsiveness follows antigen receptor engagement and results from defective signal transduction.

@article{Dubois1994TCL,
  title={T cell long-term hyporesponsiveness follows antigen receptor engagement and results from defective signal transduction.},
  author={Patrice M. Dubois and Fabienne Andris and Richard A. Shapiro and Lisa K. Gilliland and Marcelle Kaufman and Jacques Urbain and Jeffrey A. Ledbetter and Oberdan Leo},
  journal={European journal of immunology},
  year={1994},
  volume={24 2},
  pages={348-54}
}
T cell receptor (TCR)-mediated stimulation of T hybridomas leads to cell activation and lymphokine production that is followed by a long-term hyporesponsiveness. To investigate the biochemical events involved in the induction and maintenance of this antigen receptor hyporesponsiveness or anergy, we have expressed a G protein/PLC beta 1-coupled muscarinic subtype 1 acetylcholine receptor in a murine T cell hybrid. Transfected cells were capable of responding to both muscarinic agonists and TCR… CONTINUE READING