T-cell involvement in drug-induced acute generalized exanthematous pustulosis.

  title={T-cell involvement in drug-induced acute generalized exanthematous pustulosis.},
  author={Markus Britschgi and U C Steiner and Simone Schmid and Jan Paul Heribert Depta and Gabriela Senti and Andreas Bircher and Christoph Burkhart and Nikil Yawalkar and Werner Joseph Pichler},
  journal={The Journal of clinical investigation},
  volume={107 11},
Acute generalized exanthematous pustulosis (AGEP) is an uncommon eruption most often provoked by drugs, by acute infections with enteroviruses, or by mercury. It is characterized by acute, extensive formation of nonfollicular sterile pustules on erythematous background, fever, and peripheral blood leukocytosis. We present clinical and immunological data on four patients with this disease, which is caused by different drugs. An involvement of T cells could be implied by positive skin patch tests… CONTINUE READING


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