T-cell integrins: more than just sticking points.

  title={T-cell integrins: more than just sticking points.},
  author={Nancy Hogg and Melanie Laschinger and Katherine Giles and Alison McDowall},
  journal={Journal of cell science},
  volume={116 Pt 23},
T cells use integrins in essentially all of their functions. They use integrins to migrate in and out of lymph nodes and, following infection, to migrate into other tissues. At the beginning of an immune response, integrins also participate in the immunological synapse formed between T cells and antigen-presenting cells. Because the ligands for integrins are widely expressed, integrin activity on T cells must be tightly controlled. Integrins become active following signalling through other… CONTINUE READING


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