T cell-induced inflammation of the small and large intestine in immunodeficient mice.

@article{Ostanin2006TCI,
  title={T cell-induced inflammation of the small and large intestine in immunodeficient mice.},
  author={Dmitry V. Ostanin and Kevin P. Pavlick and Sulaiman Bharwani and Dwain I D'souza and Kathryn L. Furr and Carla M Brown and Matthew B Grisham},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2006},
  volume={290 1},
  pages={G109-19}
}
It is well known that transfer of CD4+CD45RBhigh (naïve) T cells into syngeneic lymphocyte-deficient mice induces chronic colitis. However, no studies have reported the presence of small bowel inflammation in this T cell-dependent model. Therefore, the objective of this study was to evaluate and compare small and large bowel inflammation induced by transfer of naïve T cells into two different immunodeficient recipient mice. T and B cell-deficient recombinase activating gene 1-deficient [RAG… CONTINUE READING
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Transfer of CD4 CD45RBhigh T-cells into TCR double deficient mice induces chronic colitis (Abstract)

  • DV Ostanin, FS Laroux, S Bharwani, MB. Grisham
  • Gastroenterology 124:
  • 2003
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