T cell inactivation and cytokine deviation promoted by anti-CD3 mAbs.

@article{Smith1997TCI,
  title={T cell inactivation and cytokine deviation promoted by anti-CD3 mAbs.},
  author={Judy A. Smith and Jeffery A. Bluestone},
  journal={Current opinion in immunology},
  year={1997},
  volume={9 5},
  pages={648-54}
}
Fc receptor nonbinding anti-CD3 monoclonal antibodies show promise for clinical application, in that they suppress graft rejection without the toxicity associated with conventional anti-CD3 antibody therapy. Recent studies suggest that the mechanism of soluble anti-CD3 antibody mediated immunosuppression involves partial signaling, induced cytokine deviation and Th1 cell inactivation. 

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