T cell immunity to herpes simplex viruses in seronegative subjects: silent infection or acquired immunity?

@article{Posavad2003TCI,
  title={T cell immunity to herpes simplex viruses in seronegative subjects: silent infection or acquired immunity?},
  author={Christine M. Posavad and Anna Wald and Nancy A. Hosken and Meei Li Huang and David M Koelle and Rhoda L. Ashley and Lawrence Corey},
  journal={Journal of immunology},
  year={2003},
  volume={170 8},
  pages={4380-8}
}
During the course of investigating T cell responses to HSV among volunteers entering trials of investigational genital herpes vaccines, 6 of the 24 immunocompetent subjects with no prior history of oral/labial or genital herpes possessed HSV-specific T cell immunity but, by multiple determinants of even the most sensitive serological assays, remained seronegative to HSV-1 and -2. Of these six immune seronegative (IS; HSV-seronegative with HSV-specific T cell responses) subjects, two had… CONTINUE READING

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