T cell homeostasis in patients with rheumatoid arthritis.

@article{Koetz2000TCH,
  title={T cell homeostasis in patients with rheumatoid arthritis.},
  author={Kerstin Koetz and Ewa D Bryl and Kay Yorck Spickschen and W. Michael O'fallon and J{\"o}rg J Goronzy and Cornelia M Weyand},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 16},
  pages={
          9203-8
        }
}
The immune system is equipped with an extremely large spectrum of structurally diverse receptors to recognize all potential antigens. This fundamental principle of receptor diversity is no longer upheld in patients with rheumatoid arthritis (RA), who have a marked contraction of the T cell receptor repertoire. In this study, the ability of RA patients to produce T cells and to maintain T cell homeostasis was examined. CD4 T cells containing T cell receptor rearrangement excision circles (TREC… CONTINUE READING
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