T-cell homeostasis: implications in HIV infection .

@article{Adleman1993TcellHI,
  title={T-cell homeostasis: implications in HIV infection .},
  author={Leonard M. Adleman and David Wofsy},
  journal={Journal of acquired immune deficiency syndromes},
  year={1993},
  volume={6 2},
  pages={
          144-52
        }
}
Evidence is presented that a homeostatic mechanism exists that maintains a normal T-cell count, but is unresponsive to abnormalities in CD4+ T-cell count and CD8+ T-cell count. Specifically, we hypothesize that in all cases of T-cell loss, whether selective or not, both CD4+ T cells and CD8+ T cells will be produced until the absolute T-cell count returns to normal, even if this produces or exacerbates abnormalities in the absolute CD4+ T-cell count and absolute CD8+ T-cell count. This… CONTINUE READING

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