T cell heterogeneity: firmly fixed, predominantly plastic or merely malleable?

@article{OShea2008TCH,
  title={T cell heterogeneity: firmly fixed, predominantly plastic or merely malleable?},
  author={John J O'Shea and Christopher A Hunter and Ronald N. Germain},
  journal={Nature Immunology},
  year={2008},
  volume={9},
  pages={450-453}
}
Do T cells modify their program of cytokine production in response to different circumstances? Or, as often assumed, do they produce a fixed set of cytokines determined after a naive cell differentiates into an irrevocably committed effector cell of a fixed type? Such questions not only are relevant to understanding host defense and optimizing vaccines but also are fundamental to understanding the pathogenesis of autoimmunity and, consequently, to the prospect of designing new immune therapies… CONTINUE READING
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