T-cell help permits memory CD8(+) T-cell inflation during cytomegalovirus latency.

@article{Walton2011TcellHP,
  title={T-cell help permits memory CD8(+) T-cell inflation during cytomegalovirus latency.},
  author={Senta Maria Walton and Nicole Torti and Sanja D. Mandari{\'c} and Annette Oxenius},
  journal={European journal of immunology},
  year={2011},
  volume={41 8},
  pages={
          2248-59
        }
}
CD4(+) T cells are implied to sustain CD8(+) T-cell responses during persistent infections. As CD4(+) T cells are often themselves antiviral effectors, they might shape CD8(+) T-cell responses via help or via controlling antigen load. We used persistent murine CMV (MCMV) infection to dissect the impact of CD4(+) T cells on virus-specific CD8(+) T cells, distinguishing between increased viral load in the absence of CD4(+) T cells and CD4(+) T-cell-mediated helper mechanisms. Absence of T-helper… CONTINUE READING
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