T cell genetic background determines maintenance of IL-12 signaling: effects on BALB/c and B10.D2 T helper cell type 1 phenotype development.

@article{Gler1997TCG,
  title={T cell genetic background determines maintenance of IL-12 signaling: effects on BALB/c and B10.D2 T helper cell type 1 phenotype development.},
  author={Mehmet L. G{\"u}ler and Nils G. Jacobson and Ueli Gubler and Kenneth M Murphy},
  journal={Journal of immunology},
  year={1997},
  volume={159 4},
  pages={1767-74}
}
In this report, we examined the molecular basis underlying the genetic difference between BALB/c and B10.D2 T cells for T helper phenotype development in vitro. We found a strain-dependent difference in early maintenance of IL-12 responsiveness by T cells developing in vitro in unmanipulated (neutral) conditions. Thus, when activated without addition of exogenous cytokines or neutralization of endogenous cytokines, B10.D2, but not BALB/c, T cells remain responsive to IL-12 when activated for 7… CONTINUE READING