T cell genetic background determines default T helper phenotype development in vitro

@article{Hsieh1995TCG,
  title={T cell genetic background determines default T helper phenotype development in vitro},
  author={C. Samuel Hsieh and S E Macatonia and Anne O'Garra and Kenneth M Murphy},
  journal={The Journal of Experimental Medicine},
  year={1995},
  volume={181},
  pages={713 - 721}
}
A host's ability to resist certain pathogens such as Leishmania major can depend upon the phenotype of T helper (Th) subset that develops. Different murine genetic backgrounds are known to significantly alter the direction of Th subset development, although the cellular basis of this influence is poorly understood. To examine the basis of this effect we used an in vitro alpha/beta-T cell receptor (TCR) transgenic system for analysis of Th phenotype development. To control for TCR usage, we… CONTINUE READING

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