T cell factor-activated transcription is not sufficient to induce anchorage-independent growth of epithelial cells expressing mutant beta-catenin.

@article{Barth1999TCF,
  title={T cell factor-activated transcription is not sufficient to induce anchorage-independent growth of epithelial cells expressing mutant beta-catenin.},
  author={Angela I. M. Barth and Daniel B. Stewart and W. James Nelson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 9},
  pages={4947-52}
}
N-terminal mutations in beta-catenin that inhibit beta-catenin degradation are found in primary tumors and cancer cell lines, and increased beta-catenin/T cell factor (TCF)-activated transcription in these cells has been correlated with cancer formation. However, the role of mutant beta-catenin in cell transformation is poorly understood. Here, we compare the ability of different N-terminal mutations of beta-catenin (DeltaN131, DeltaN90, DeltaGSK) to induce TCF-activated transcription and… CONTINUE READING

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