T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance

@article{Pesu2008TcellexpressedPC,
  title={T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance},
  author={Marko Pesu and Wendy T Watford and Lai Wei and L. Z. Xu and Ivan Fuss and Warren Strober and John Andersson and Ethan M Shevach and Martha Quezado and Nicolas Bouladoux and Anton J. M. Roebroek and Yasmine Belkaid and John W. M. Creemers and John J. O’Shea},
  journal={Nature},
  year={2008},
  volume={455},
  pages={246-250}
}
Furin is one of seven proprotein convertase family members that promote proteolytic maturation of proproteins. It is induced in activated T cells and is reported to process a variety of substrates including the anti-inflammatory cytokine transforming growth factor (TGF)-β1 (refs 2–4), but the non-redundant functions of furin versus other proprotein… CONTINUE READING